CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment, MeSH Methods: 6.Patients with fever over 38.5 , should go to the hospital. If substantial heterogeneity is identified, we will report it and explore possible causes using sensitivity analysis and subgroup analysis. [16] All data generated or analyzed during this study are included in this published article [and its supplementary information files]. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsule are as follows: First, Higgins JPT, Thompson SG, Deeks JJ, et al. [35]. The 3 drugs and 3 parties in China have been effective in many countries around the world, and once again reveal the special advantages of the Chinese herbal medicine overall adjustment and multi target therapy, which suggests the application of Lianhua Qingwen granule. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in the control group (n=33). Chunyuan Liu, Xiaoqiang Li, Shaoqian Cai. [1]. The Daily Guardian is a renascent Iloilo-based publishing firm and media outfit with bureaus in Kalibo, Boracay, Roxas, Bacolod, Antique, Guimaras, and Manila. Is there any notice for taking Lianhua Qingwen Capsules? [31] The results will be interpreted carefully based on several explanations for funnel plot asymmetry. Sign in to listen to groundbreaking journalism. TheChinese researchers also claim thatLHQWisa classical Chinese medical preparation and that itscapsules or granulesareconsist of 11 herbs, gypsum,and mentholwhich are recorded in the2015 Edition ofthe ChinesePharmacopoeia. Lianhuaqingwen (LHQW) has anti-inflammatory and immune regulatory functions and may inhibit the airway inflammation that occurs during an acute exacerbation of COPD. Manufacture address: No.238 Tianshan street, New and high development area, Shijiazhuang, Hebei, China. There are an increasing number of studies on for COVID-19 published with inconclusive results in recent. Go and see the doctor if the symptom is not alleviated 3 days after administration. [2]. 2022 Jan;20(1):26-33. doi: 10.1016/j.joim.2021.10.005. Subgroup analysis and sensitivity analysis will be performed to explore the causes of heterogeneity. 1. If I2 test <50%, a fixed-effects model will be used to pool the data. 10. Learn more. Designed by ACTSmarket. Drug discoveries & therapeutics 2020;14:6772. The .gov means its official. The research results revealed that Lianhua Qingwen Capsules effectively improved the total effective rate of COVID-19 treatment, as it significantly ameliorated the symptoms of cough, fever and fatigue of patients, improved the disappearance rate of main symptoms, and shortened the duration of main symptoms on the basis of routine treatment. Avoid alcohol and tobacco and spicy,cold, greasy food during taking this product. Egger M, Davey Smith G, Schneider M, et al. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology[32] will be used to assess the quality of the evidence and risk of bias with on-line GRADE (https://www.gradeworkinggroup.org/). You may be trying to access this site from a secured browser on the server. Announcement of the national health and Health Commission of the people's Republic of China [EB /OL] (2020-01-20) [20200217]. government site. [Storage]Preserve in tightly closed containers, stored in a cool and dry place (20). [4] However, at present, there is no effective antiviral treatment drug confirmed for covid-19. All reports of the randomized controlled trials (RCTs) on Lianhua Qingwen capsule treating influenza http://creativecommons.org/licenses/by/4.0. [30] The I2 statistic of <50% indicates a low level of statistical heterogeneity, and that of 50% will be considered substantial statistical heterogeneity. She can be reached atbandiolateresamayb@gmail.com. Recently, the novel coronavirus pneumonia (COVID-19) epidemic has spread continuously and has been classified as class B infectious diseases (class a management). [Administration and Dosage]For oral administration, 4 capsules once, 3 times daily. [Contraindications]Those who are allergic to this product and its ingredients should not take it. 4.Patients with diabetes patients,high blood pressure, heart diseases, liver disease, kidney disease and other severe chronic diseases shall take medicine under guidance of physician. In 2017, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (Version 1)(2017) , issued by the National Health and Family Planning Commission Exclusion: studies using two or more Chinese herbal compound as intervention measures will be excluded. This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, Therefore, it is essential to perform a systematic review and meta-analysis to assess the effect of Lianhua Qingwen combined with conventional antiviral Western Medicine in clinical treatment of COVID-19 or asymptomatic infection. The Potential of Ameliorating COVID-19 and Sequelae From. [15]. For novel coronavirus pneumonia, the total effective rate of TCM is over 90%.[EB/OL]. Post code: 050035 Tel: 0086-311-85901643 Fax: 0086-311-85906730 Website: http://www.yiling.cn Any questions or problems, please do not hesitate to contact manufacturer. 3.2. In addition, we learned from the experience of Rhubarb in the treatise on Febrile Diseases in the treatment of epidemic diseases. How to take it to realize the maximal efficacy? Lu Y, Zhang M, Yang QQ, Li WJ, Yang K, Hu W, Gao SY, Jiang QL, Lin LK, Cheng H, Sun F. Evid Based Complement Alternat Med. [25]. 2018;Beijing: Science and Technology Literature Press, 13271329. Correspondence: Mingjun Liu, and Xiaolin Zhang, professor, Changchun University of Chinese Medicine, 1035 Boshuo Road, Jingyue Economic Development Zone, Changchun City, Jilin Province 130117, China (e-mail: [emailprotected], [emailprotected]). Guyatt GH, Oxman AD, Vist GE, et al. Add your comment to start the conversation. TheDangerous Drug Board (DDB)considers ephedrine as a dangerous drug, andthose found to be sources are also classified as dangerous drugs. Select all eligible studies published before May 8, 2020. National Health and Family Planning Commission of the people's Republic of China. 8.Three days without any remission,or symptems aggravated,appeared new serious symptems, should go to hospital. Risk ratio (RR) was used to express the severe conversion rate and CT improvement rate absorption rate; mean difference (MD) was used to express the time of fever reduction in secondary indexes; Odds Ratio (OR) was used to express clinical efficiency and symptom disappearance rate. In 2013, Expert Consensus on Medical Treatment for Patients Infected with H7N9 Avian Influenza (2013), issued by the National Health and Family Planning Commission Avoid prolonged use. Available at: [30]. Rappler.com. eCollection 2023. Holshue ML, DeBolt C, Lindquist S, et al. Data curation: Xiaolin Zhang, Di Cao, Qi Zhang, Junnan Liu. It has important clinical application value to treat patients with covid-19. Study on the effect of Lianhuaqingwen Granule on BALB /c mice infected with respiratory syncytial virus [J]. Forsythiae Fructus, Lonicerae Japonicae Flos, Ephedrae Herba (processed with honey), Armeniacae Semen Amarum (stir-baked), Gypsum Fibrosum, Isatidis Radix, Dryopteridis Crassirhizomatis Rhizoma, Houttuyniae Herba, Pogostemonis Herba, Rhei Radix et Rhizoma, Rhodiolae Crenulatae Radix et Rhizoma, l-Menthol, Glycyrrhizae Radix et Rhizoma. Wu C, Chen X, Cai Y, et al. your express consent. Traditional Chinese medicine Lianhua Qingwen treating corona virus disease 2019(COVID-19): Meta-analysis of randomized controlled trials. [22]. XLZ conceived of the study, and perform this review. Lianhua Qingwen combined with conventional drugs may be a promising therapy for treating common pneumonia and COVID-19 pneumonia. In accordance with the usage and dosage,the product should not be long term used. Wang Y, Zhang D, Du G, et al. COVID-19; Lianhua Qingwen; meta-analysis; protocol; systematic review. Epub 2021 Nov 2. Please try after some time. ACTSmarket.com is the e-shop and distribution arm of ACTSmarket Ltd, Now. [17]. The effect of Lianhuaqingwen Capsule on the expression of inflammatory factors and connexin in lipopolysaccharide induced acute lung injury mice [J]. Cao B, Wang Y, Wen D, et al. Web[Administration and Dosage] For oral administration, 4 capsules once, 3 times a day. [34]. STATA15.1 and RevMan5.3 software were used to analyze meta outcomes of different intervention measures for the treatment of new crown pneumonia and the control group (conventional antiviral western medicine treatment) clinical efficacy. Consult with doctors or pharmacists before administration if other medicines are received during this time. Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. See this image and copyright information in PMC. Novel coronavirus pneumonia treatment plan issued by the national health and Health Committee, State Administration of traditional Chinese medicine (trial version sixth) [EB/OL]. WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba [Main Ingredients] Avoid receiving nourishing Chinese medicine during the period in this product. [3] It is reported that 4,430,100 cases have been confirmed in the world, and 299,451 cases have died. Journal of Guangzhou University of traditional Chinese medicine, 2016 33:5404. The results will be cross-checked by the 2 reviewers, and any disagreements will be resolved by consensus, with any ongoing differences in opinion being arbitrated by a third reviewer (LMJ). [36]. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cao B, Zhang D, Wang C. A trial of lopinavir-ritonavir in, [6]. sharing sensitive information, make sure youre on a federal Children, pregnant women, nursing mother, senile and infirm patients or those with week spleen should take medicine under doctors direction. Bethesda, MD 20894, Web Policies Should not be used for wind-cold common cold. In 2014, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (2014), issued by the National Health and Family Planning Commission The full text of articles potentially suitable for the review will be obtained for further assessing eligibility based on the inclusion criteria or/and exclusion criteria. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). If I2 test 50%, a random-effects model will be used for data analysis instead. The site is secure. https://en.prnasia.com/releases/global/tcm-lianhua-qingwen-shows-stable-in-vitro-antiviral-effect-on-the-delta-variant-expert-327965.shtml, Lianhua Qingwen Jiangnan (LHQW) for Flu and Colds. Copyright 2023 MIMS Pte Ltd. All rights reserved. Chinese Journal of nosocomial infection 2015;25:7279. In WANFANG, novel coronavirus pneumonia, 2019-nCOV, COVID-19, and SARS-COV-2 were first searched for the keywords, then searched for the theme word Lianhua Qingwen and Lianhua Qingke. The 2 search were merged with the relationship. Novel coronavirus pneumonia is being set up by CNKI for the new research project. The authors have no conflicts of interest to disclose. [Functions and Indications]Clear heat and detoxify, remove lung hotness. Molecules. Two reviewers (XLZ and JNL) will assess the eligibility of the studies retrieved during the searches independently using the inclusion and exclusion criteria. Buy > 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). To systematically determine the effect of Lianhua Qingwen Capsules on the early antiviral and anti-inflammatory action against COVID-19 (Coronavirus 2019) and its applicational value in the treatment of COVID-19. Traditional Chinese medicine, such as Lianhua Qingwen, has achieved some curative effect in many countries, but its effect is not clear. In addition, it can also interact with other compounds and herbs. Asia's one-stop resource for medical news, clinical reference and education, Philippine Archipelago International Trading, Click to view Lianhua Qingwen detailed prescribing information. This site needs JavaScript to work properly. cDepartment of lung diseases, the Third Clinical Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China. Preliminary study on the inhibitory effect of three traditional Chinese medicine prescriptions on SARS related coronavirus in vitro [J]. HHS Vulnerability Disclosure, Help Biotechnology communication 2003;14:3902. Preliminary study on the inhibitory effect of three prescriptions of traditional Chinese medicine on SARS related coronavirus in vitro [J]. The independent Newcastle Ottawa scale was used to conduct methodological quality assessment of nonrandomized trials. The rate of positive nucleic acid detection of COVID-19 from intranasal and pharyngeal swabs was significantly lower in the treatment group [29]. [21]. 9 Experimental research also showed that LH exerted broad-spectrum effects on a series of influenza viruses by inhibiting viral propagation and regulating immune function. Avoid spicy & greasy food during medication. Here are links to the publications that published the results of the clinical trial :https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229744/https://en.prnasia.com/releases/global/tcm-lianhua-qingwen-shows-stable-in-vitro-antiviral-effect-on-the-delta-variant-expert-327965.shtmlIngredients & ContradicationsPlease refer to the pictures for more informationUSAGE FOR RESPIRATORY DISEASES SUCH AS FLUS AND COLDSProphylaxis: If you know you are going out, take LHQW the day before, the day of the outing and the day after the outing. Used in treatment of epidemic influenza and lung heat, symptom as fever or high fever, aversion to cold, muscular soreness, rhinostegnosis and nasal discharge, cough, headache, dry and sore throat, flushing tongue, or greasy fur of tongue. National Bureau of disease control and prevention. >10 to <14 years old: 3capsules x 3 times a day ( after breakfast, lunch and dinner).> 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). Patients with body temperature higher than 38.5 should see the doctor. In the fifth edition of COVID-19's diagnosis and treatment guideline issued by the China Health Commission, LHQWG is listed as one of the recommended medicine It contains 13 herbs that are anti-viral and anti-inflammatory. As a drug, ephedrine is a decongestant and bronchodilator. Delivery takes 2 business days & another 2 calendar days for order processingPROMO OFFER ( completed & over) : Buy 1 Bundle, We Donate 1 Bundle ! After determining how to combine different types of studies, NRIs use the method of inverse variance of random-effect model to evaluate and calculate the 95% CI of the effect value. Meanwhile, China also provides technical solutions through long-distance video exchanges to share treatment experience with Japan, South Korea, Italy, the United States, Iran, Singapore, and so on. Published by Wolters Kluwer Health, Inc. 1. general information: title, authors, year of publication, and Study area, average age, average course of disease and treatment time; 2. trial characteristics: design, duration of follow-up, method of randomization, allocation concealment, incomplete outcome data, blinding (patients, people administering treatment, outcome assessors); 3. intervention(s): intervention(s) (The dosage form of. How to cite this article: Zhang X, Cao D, Liu J, Zhang Q, Liu M. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. You may search for similar articles that contain these same keywords or you may How to Use: Dosage: Consume orally 4 capsules each, 3 times daily after meal. If you buy two boxes at a time, or an integral multiple of two boxes (such as 4 boxes or 6 boxes), we will give you one box for every two boxes. [20]. It includes forsythia, honeysuckle, ephedra (ma huang), armeniacae, gypsum, isatis, dryopteridis, houttuynia, pogostemon, rheum, rhodiola, Chinese peppermint (bohe), and liquorice. Wu Yiling. In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. Though no specific drug has been developed so far, emerging agents have been confirmed effective or potentially beneficial to restrain it. Shunya Zhu, Xiaoying Li, Yunling Wei, et al. Kupferschmidt K, Cohen J. For the treatment of influenza due to heat-toxic attack lung, syndrome see: fever or serious fever,aversion to cold, muscle soreness, stuffy nose, runny nose, cough, headache, throat dry and sore throat, red tongue, yellow or yellow greasy tongue coating and so on. World Healthy Organization. Bookshelf FDA Phase-II Clinical Study, In 2020, Diagnosis and Treatment Scheme for Novel Coronavirus Pneumonia, jointly issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine 2 capsules per dose. [Adverse Reactions]Post-marketing monitoring data show that this product may cause gastrointestinal adverse reactions such as nausea, vomiting, abdominal pain, diarrhea, bloating, as well as rash, itchy ulcers, dry mouth, dizziness. Writing review & editing: Xiaolin Zhang. 7. Lianhua Qingwen combined with conventional antiviral Western Medicine may be a useful treatment for prediabetes. We will perform the sensitivity analysis to explore the effects of trial risk of bias on primary outcomes if possible. modify the keyword list to augment your search. WebDosage: 2 capsules twice a day ( after breakfast & dinner) >14 years & above: 4 capsules x 3 times a day ( after breakfast, lunch and dinner) for 7 to 10 days. In addition, only studies published in English and Chinese will be searched and included because of language barriers, so a language bias may exist. Biotechnology communication 2003;14:3902. National Library of Medicine Siwen Tang, Yanfen Zhang, Kejian Liu, et al. To consume within 2 weeks after opening. Statistical analysis was conducted by Revman 5.3 software. There is no effective antiviral drug for COVID-19. Yizhu Wang, Hongtao Wang, Xue Han, et al. Hermetically sealed,keep in cool and dry places. Placebo, routine western medicine therapy, and other therapeutic methods in the comparators (drugs, dose, frequency, duration); (5) Outcomes: the primary outcomes include total efficiency, primary symptoms, and Excluded from the meta-analysis are duplicated publications; the control group also used traditional Chinese medicine intervention, studies with unavailable or incorrect data, articles not reporting outcomes of interest. Kunming: Kunming University of technology; 2015. Novel coronavirus pneumonia is a new method for the treatment of new crown pneumonia. A: Chest radiograph of normal people; B: Chest radiograph of a patient with early-mid-stage COVID-19. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. Highlight selected keywords in the article text. Zhongguo Zhong Yao Za Zhi. Contraindicated for the patients allergic to this product, be cautions about patients with allergic constitution. It has a wide-spectrum antiviral, effective antibacterial, antipyretic and anti-inflammatory, antitussive and expectorant, immune-regulating and other systemic intervention functions,[1625] especially for the coronavirus SARS[26] And Middle East respiratory syndrome (MERS)[27] have significant inhibitory and killing effects. Patients with hypertension or heart disease should use with caution, patients with chronic disease such as diabetes, liver disease, kidney disease should take medicine under doctors direction. The Cochrane Collaboration, Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions (Version 5.1.0). Medicine. If you are using other drugs, please consult your doctor before using this product. [24]. Effect of aqueous extract of Lianhuaqingwen Capsule on bacterial biofilm of methicillin-resistant Staphylococcus aureus [J]. Press the space key then arrow keys to make a selection. It cannot be bought over-the-counter and not recommended for self-medication. The following data will then be extracted from the studies selected for inclusion using a data collection form, and recorded onto an Excel file: first author and year, study design, sample, intervention, type of measures, risk of bias assessment, and findings. The findings of the trial showed strong indications of LHQW in helping patients recover faster and in the prevention of severe covid disease, when compared to the control group using only standard treatment. Among the many commonly used TCMs, the most commonly used one is Lian-Hua Qing-Wen Granule (LHQWG). Ephedra increases heartbeat and blood pressure. It is compatible with Rhodiola to clear lung and remove blood stasis. 2020 Sep 11;15(9):e0238828. Choosing a selection results in a full page refresh. For more information, please refer to our Privacy Policy. Bioinform Biol Insights. Hongying Mo, Zifeng Yang, Jinping Zheng, et al. [59] In the early stage, there is no specific medicine or vaccine; the intervention of Chinese traditional medicine compound Lianhua Qingwen and other traditional Chinese medicine have played an important role. Tips: Please read the directions for use in retail or directed by physician. Some notable dangerous reactions include heart attacks, strokes, seizures, and sudden deaths. Open the moisture-proof bag, please pay attention to prevent moisture. Also indicated for the symptoms of fever, cough, and fatigue caused by the mild and moderate coronavirus disease 2019 (COVID-19) in combination with standard of care. [31]. The proportion of severe patients admitted to covid-19 hospital is 15.7%, and the death rate of confirmed patients is 6.7%. WebFor patients showing mild symptoms, Lianhua Qingwen would be more effective. In 2018, Diagnosis and Treatment Scheme for Influenza (2018), issued by the National Health and Family Planning Commission National Key New Product In 2011, Diagnosis and Treatment Guide for Influenza (2011), issued by the Ministry of Health The novel coronavirus pneumonia (COVID-19) has spread to >200 countries and regions. WebAs chemical analysis for quality control (QC) of traditional Chinese medicine (TCM) formula is difficult to guarantee the effectiveness, a bioassay method that combines QC with evaluation of therapeutic effects has been developed to assess the TCM quality. BackgroundLHQW's formulation is based on two ancient formulae from the Han and Qing dynasties - Maxing Shigan decoction and Yinqiao powder - following the SARS epidemic. A funnel plot will be constructed and examined to assess publication bias and possible small study biases if the group include more than 10 trials. All randomized controlled trials (RCTs), Retrospective cohort study (RCSs), Comparison before and after the study (BAs) of Lianhua Qingwen combined with Conventional antiviral Western Medicine for COVID-19 will be included. [Drug Interactions]Interaction may appear if administered accompanied with other medicine, consult with doctors or pharmacists for details. 2022 Aug 19;27(16):5292. doi: 10.3390/molecules27165292. The product should beprescribed by a physician with a PDEA S-2 license. [14]. Max: 7 days. At the same time, the single arm study was included in the analysis, not involved in data synthesis, only used to assist in displaying the clinical characteristics of the subjects, not for efficacy evaluation. "It's the first time in the world that we have enough evidence to prove Lianhua Qingwen Jiaonang capsule is effective and can help patients recover," Zhong said, adding they have just finished an experiment and the results are promising and werepublished. Part of the goods frequent replacement of packaging, such as goods and pictures are not exactly the same, please refer to the goods you receive. FREE SHIPPING within SG when you buy 4 boxes or more. The general public is reminded that LHQW is only a traditional Chinese medicine and not a therapeutic drug for Covid-19. The protocol will be disseminated in a peer-reviewed journal or presented at a relevant conference. WebLianhua Qingwen Jiaonang with Chinese Characters; As per continuing post-marketing surveillance, there is still incessant sale and distribution even through social media platforms, such as Facebook, of Lianhua Qingwen Jiaonang with Chinese characters, which were verified as unregistered by the FDA. Experimental study of Lianhuaqingwen capsule against influenza A virus in vitro [J]. Clearing away heat toxic materials,open the inhibited lung-energy and clearing away lung heat. Nausea, diarrhea, vomiting, abdominal pain, dry mouth, rash, itching, dizziness. Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. [26]. eCollection 2023. Zhong said that, according to the experiment,the Lianhua Qingwen Jiaonang capsule can weakly inhibit the virus and repair cell injuries and inflammation caused by the virus. Lianhua Qingwen Capsules can significantly improve the total effective rate for COVID-19 patients, as well as shorten the hospital stay and treatment time, which is worth of promotion in the clinic. Please enable it to take advantage of the complete set of features! Hongtao Lei, Shutu Ma, Xiuxin Jiang, et al. WebDosage/Direction for Use 4 cap tid w/ warm water. Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. SHI JIA ZHUANG YI LING PHARMACEUTICAL CO.,LTD. The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by the national Wei Jian administration and the State Administration of traditional Chinese medicine for 20 times. 2011. Zhao Liu, Fuzhong Shi, zhanqiu Yang. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. Children should be administered under adults supervision. Its formulation includes 13 herbs which are said to have been used for medical purposes as early as the Han dynasty. Any disagreement will be resolved by consensus or discussion with a 3rd party (MJL). may email you for journal alerts and information, but is committed It is based on the published clinical research literature at present stage. Keyword Highlighting Nausea, vomiting, abdominal pain, diarrhea, bloating. Coronavirus disease 2019 (, [5]. 10 Why is it important to subscribe? Chinese Journal of pharmacology and toxicology 2015;29:2137. Dont take this medicine if the description has changed. High heterogeneity may also arise from the various evaluations. Primary Endpoints. GRADE: an emerging con- sensus on rating quality of evidence and strength of recommendations[J]. We aim to assess the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in Clinical treatment of COVID-19 or asymptomatic infection. [10]. The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by XLZ and JNL will assess the risk of bias and perform data synthesis. All tests are 2-tailed, and P < .05 is considered statistically significant. It has important clinical significance for alleviating the severity of COVID-19 and shortening the course of disease. Also illustrates the potential biases within each of the included studies by presenting a risk of bias," table, graph, and summary. In 2019, Diagnosis and Treatment Scheme for Influenza (2019), issued by the National Health Commission Early Treatment>14 years & above:4capsules x 3 times a day ( after breakfast, lunch and dinner) for7 to 10 days. V03AX - Other therapeutic products ; Other products with therapeutic properties. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. The following electronic bibliographic databases will be searched to identify relevant studies: CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as China Clinical Trial Registration Center (ChiCTR), Netherlands National Trial Registration Center (NTR) and clinical trials.gov. To add, theonline sale and distribution ofthis productis prohibited and those engaging in this activityviolatethe R.A.10918orPhilippine Pharmacy Act. For oral use after meals,4 capsules one time and thrice daily. Whether a fixed-effects or a random-effects model will be used depends on the results of I2 test for heterogeneity. This product should be administered strictly in accordance with dosage and administration, and is not for long-term use. In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group.
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